| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376288 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact on the treatment of several degenerative diseases. Here we report the synthesis of reversible inhibitors via a solid-support palladium-catalyzed amination of 3-bromopyrazinones and the discovery of a pan-caspase reversible inhibitor.
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Authors
Elise Isabel, Renee Aspiotis, W. Cameron Black, John Colucci, Réjean Fortin, André Giroux, Erich L. Grimm, Yongxin Han, Christophe Mellon, Donald W. Nicholson, Dita M. Rasper, Johanne Renaud, Sophie Roy, John Tam, Paul Tawa, John P. Vaillancourt,