| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376298 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tao Guo, Huizhong Gu, Doug W. Hobbs, Dennis E. Busler, Laura L. Rokosz,