| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376299 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.
Graphical abstractHigh-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a) are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jian Jin, Yonghui Wang, Feng Wang, Jeffery K. Kerns, Victoria M. Vinader, Ashley P. Hancock, Matthew J. Lindon, Graeme I. Stevenson, Dwight M. Morrow, Parvathi Rao, Cuc Nguyen, Victoria J. Barrett, Chris Browning, Guido Hartmann, David P. Andrew,