| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376304 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.
Graphical abstractA series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain](/preview/png/1376304.png "First Page Preview: Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain")
Authors
Anne-Marie Liberatore, Jocelyne Schulz, Christine Favre-Guilmard, Jacques Pommier, Jacques Lannoy, Emilia Pawlowski, Marie-Anne Barthelemy, Marion Huchet, Michel Auguet, Pierre-Etienne Chabrier, Dennis Bigg,