Article ID Journal Published Year Pages File Type
1376308 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70° side-chain rotation to accommodate the inhibitor and allows access to a previously unexposed area of the protein backbone for hydrogen bonding.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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