4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function

The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.

Graphical abstractNovel oxazolidinone RNA ligands that modulate T box riboswitch function are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide