Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

Graphical abstractNovel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of enoyl-ACP reductase from Bacillus anthracis.Figure optionsDownload full-size imageDownload as PowerPoint slide