Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376352 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the structures and bioactivity of these compounds, a series of monoglycerides were synthesized using glycerol and various fatty acids. Several compounds exhibited moderate to significant inhibition of phospholipase A2 and cyclooxygenase-2.
Graphical abstractThe isolation, synthesis, and bioactivity of fatty acid-derived monoglycerides are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hyeun Wook Chang, Kyoung Hwa Jang, Doohyun Lee, Hee Ryong Kang, Tae-Yoon Kim, Bong Ho Lee, Byoung Wook Choi, Sanghee Kim, Jongheon Shin,