| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376354 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
Graphical abstractSome dumbbell-shaped circular oligonucleotides containing C3-spacer modifications and Topo I-binding sites were synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by certain DNA repair enzyme.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yifan Wang, Magdeline Tao Tao Ng, Tianyan Zhou, Xinming Li, Choon Hong Tan, Tianhu Li,