Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway

We herein report the design and synthesis of furoquinoline based novel molecules (16–36) and their in vitro multiple targeted inhibitory potency against PI3K/Akt phosphorylation and mTOR using cell based and cell-free kinase assay. In particular, compound 23 in addition to PI3K-mTOR inhibitory potency, it has shown potent inhibition of hypoxia-induced accumulation of HIF-1α protein in U251-HRE cell line. The inhibitory activities of compound 23 were confirmed by Western blot analysis, using human non-small cell lung carcinoma H-460 cell line and glioblastoma U251 cell lines.

Graphical abstractA variety of furoquinoline based novel molecules have been designed, synthesized and evaluated as multiple target inhibitor of PI3K/Akt-mTOR pathway. Compound (23) has shown significant inhibition of PI3K/Akt-mTOR-HIF-1α.Figure optionsDownload full-size imageDownload as PowerPoint slide