Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376358 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3k, which displayed potent inhibitory activities in biochemical and replicon assays (IC50 (1b) < 10 nM; EC50 (1b) = 12 nM) as well as good stability towards human liver microsomes (HLM t1/2 > 60 min).
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Related Topics
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Chemistry
Organic Chemistry
Authors
Frank Ruebsam, Stephen E. Webber, Martin T. Tran, Chinh V. Tran, Douglas E. Murphy, Jingjing Zhao, Peter S. Dragovich, Sun Hee Kim, Lian-Sheng Li, Yuefen Zhou, Qing Han, Charles R. Kissinger, Richard E. Showalter, Matthew Lardy, Amit M. Shah, Mei Tsan,