Article ID Journal Published Year Pages File Type
1376360 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these molecules revealed two distinct classes of compounds that inhibit ThyX with submicromolar concentrations, which could lead, after optimization, to effective inhibitors with potential biomedical interest.

Graphical abstractThe synthesis of potent thymidylate synthase X inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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