Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376360 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these molecules revealed two distinct classes of compounds that inhibit ThyX with submicromolar concentrations, which could lead, after optimization, to effective inhibitors with potential biomedical interest.
Graphical abstractThe synthesis of potent thymidylate synthase X inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
F. Esra Önen, Yap Boum, Claire Jacquement, Maria Vittoria Spanedda, Nada Jaber, Daniel Scherman, Hannu Myllykallio, Jean Herscovici,