| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376366 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.
Graphical abstractFollowing the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines](/preview/png/1376366.png "First Page Preview: IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines")
Authors
George M. Buckley, Richard Fosbeary, Joanne L. Fraser, Lewis Gowers, Alicia P. Higueruelo, Lynwen A. James, Kerry Jenkins, Stephen R. Mack, Trevor Morgan, David M. Parry, William R. Pitt, Oliver Rausch, Marianna D. Richard, Verity Sabin,