| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376380 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Structure–activity relationship studies on 1α,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), antagonists of vitamin D, were conducted, focusing on the substituents of the phenyl group. One of the derivatives (23S,25S)-DLAM-1P-3,5(OEt)2, showed potent antagonistic activity with an IC50 of 90 nM.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Kaori Cho, Fumito Uneuchi, Yuko Kato-Nakamura, Jun-ichi Namekawa, Seiichi Ishizuka, Kazuya Takenouchi, Kazuo Nagasawa,