| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376400 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
Graphical abstractAn early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bolin Geng, Gloria Breault, Janelle Comita-Prevoir, Randy Petrichko, Charles Eyermann, Tomas Lundqvist, Peter Doig, Elise Gorseth, Brian Noonan,