| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376406 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.
Graphical abstractThe discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides as CCK1R agonists are reported. Compound 44 exhibited excellent lean mouse overnight food intake reduction.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheng Zhu, Alexa R. Hansen, Thomas Bateman, Zhesheng Chen, Tom G. Holt, James A. Hubert, Bindhu V. Karanam, Susan J. Lee, Jie Pan, Su Qian, Vijay B.G. Reddy, Marc L. Reitman, Alison M. Strack, Vincent Tong, Drew T. Weingarth, Michael S. Wolff,