| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376484 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new 99mTc-deoxyglucose derivatives showed accumulation in tumor and high tumor-to-muscle ratios. Among them, the 99mTc-MAG3-DG showed the best characteristics as a potential tumor marker for single photon emission computed tomography (SPECT).
Graphical abstractThe synthesis and evaluation of three 99mTc-labeled-deoxyglucose derivatives, 99mTc-S-DG, 99mTc-MAG3-DG, and 99mTc-MAMA-BA-DG were reported here.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiangji Chen, Liang Li, Fei Liu, Boli Liu,