| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376491 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gaiying Zhao, Marvin J. Miller, Scott Franzblau, Baojie Wan, Ute Möllmann,