| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376492 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists.
Graphical abstractSystematic optimisation of a previously described series of novel VLA-4 antagonists has identified a potent orally bioavailable VLA-4 integrin antagonist.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jason Witherington, Emma L. Blaney, Vincent Bordas, Richard L. Elliott, Alessandra Gaiba, Neil Garton, Philip M. Green, Antoinette Naylor, David G. Smith, David J. Spalding, Andrew K. Takle, Robert W. Ward,