Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376495 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
As part of a program to design rational, mechanism-based inhibitors of guanase, we report here the synthesis and biochemical screening of two analogues of azepinomycin (1 and 2), a naturally occurring inhibitor of guanase, known to mimic the transition-state of the enzyme-catalyzed reaction. Our biochemical results show that compounds 1 and 2 are competitive inhibitors with Ki of 2.01 ± 0.16 × 10−5 and 5.36 ± 0.14 × 10−5 M, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi K. Ujjinamatada, Anila Bhan, Ramachandra S. Hosmane,