| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376496 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of metabolically stable butyrolactam 11β-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity, pharmacokinetic, and pharmacodynamic profiles.
Graphical abstractA series of metabolically stable butyrolactam 11β-HSD1 inhibitors have been synthesized and biologically evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vince S.C. Yeh, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, Robin Shapiro, Victoria Knourek-Segel, Eugene Bush, Denise Wilcox, Phong T. Nguyen, Michael Brune, Peer Jacobson, J.T. Link,