| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376501 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
The catecholic xanthones and flavonoids 1–13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3–8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10–12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.
Graphical abstractThe catecholic xanthones and flavonoids 1–13 were isolated from the chloroform extracts of the root bark of Cudrania tricuspidata. Compounds 1 and 3–8 exhibited significant antioxidant activity against LDL oxidation in TBARS assay. Among them, 10–12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.Figure optionsDownload full-size imageDownload as PowerPoint slide
