| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376504 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters from Aquifex aeolicus (LeuTAa). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aina Westrheim Ravna, Malgorzata Jaronczyk, Ingebrigt Sylte,