| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376505 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Utilizing modeling information from a recently resolved structure of human HIF-1α prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a human EGLN1 assay and a limited SAR was developed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Namal C. Warshakoon, Shengde Wu, Angelique Boyer, Richard Kawamoto, Justin Sheville, Sean Renock, Kevin Xu, Matthew Pokross, Artem G. Evdokimov, Richard Walter, Marlene Mekel,