Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376509 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Structure-guided de novo drug design led to the identification of a novel series of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors. Pyridine carboxyamide derivatives bearing a substituted aryl group at the 5-position of the pyridine ring show appreciable activity, while constraining the side chain by placing a pyrazole carboxylic acid generated a potent lead series with consistent activity against EGLN-1.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Namal C. Warshakoon, Shengde Wu, Angelique Boyer, Richard Kawamoto, Justin Sheville, Ritu Tiku Bhatt, Sean Renock, Kevin Xu, Matthew Pokross, Songtao Zhou, Richard Walter, Marlene Mekel, Artem G. Evdokimov, Stephen East,