Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues

Two series of dioscin derivatives (4a–o and 5a–o) with selected modifications at the 6′ and 4‴ positions of the chacotriosyl residue, respectively, were synthesized. All the 6′-N-acyl-dioscin derivatives did not show considerable inhibitory activities at 10 μM, while most of the 4‴-O-(2-N-acyl)ethyl-dioscin derivatives behaved as potent as dioscin, against the growth of tumor cells.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide