| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376528 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained good activity compared to cyclosporin A and the original reversins.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ali Koubeissi, Imad Raad, Laurent Ettouati, David Guilet, Charles Dumontet, Joelle Paris,