Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway.

Graphical abstractThe synthesis and biological evaluation of a series of thieno[3,2-b]pyridine inhibitors of the tyrosine kinases c-Met and VEGRF2 is described.Figure optionsDownload full-size imageDownload as PowerPoint slide