| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376542 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Susan D. Aster, Donald W. Graham, Divya Kharbanda, Gool Patel, Mitree Ponpipom, Gina M. Santorelli, Michael J. Szymonifka, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Rolf Thieringer, Anne Hermanowski-Vosatka, Samuel D. Wright, Jianying Xiao,