| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376546 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A new series of 1,5-and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3-5.1 μM) and selectively over other proteins involved in the endocannabinoids activity and metabolism.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Giorgio Ortar, Aniello Schiano Moriello, Maria Grazia Cascio, Luciano De Petrocellis, Alessia Ligresti, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo,