| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376547 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Computer aided modeling guided the design of a series of diarylimidazole compounds (11–22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
Graphical abstractDiarylimidazole motifs were designed to interact with both the ATP binding site and the adjacent allosteric region.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ronald L. Wolin, Scott D. Bembenek, Jianmei Wei, Shelby Crawford, Katherine Lundeen, Anders Brunmark, Lars Karlsson, James P. Edwards, Jonathan M. Blevitt,