| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376550 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.
Graphical abstractA series of small molecule inhibitors of the lymphoid specific tyrosine phosphatase were described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuli Xie, Yidong Liu, Gangli Gong, Alison Rinderspacher, Shi-Xian Deng, Deborah H. Smith, Udo Toebben, Effie Tzilianos, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Lutz Tautz, Donald W. Landry,