| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376551 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James R. Corte, Tianan Fang, Donald J.P. Pinto, Wei Han, Zilun Hu, Xiang-Jun Jiang, Yun-Long Li, Jolicia F. Gauuan, Mark Hadden, Darren Orton, Alan R. Rendina, Joseph M. Luettgen, Pancras C. Wong, Kan He, Paul E. Morin, Chong-Hwan Chang,