Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376554 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.
Graphical abstractA series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a are described.Figure optionsDownload full-size imageDownload as PowerPoint slide