Article ID Journal Published Year Pages File Type
1376555 Bioorganic & Medicinal Chemistry Letters 2008 6 Pages PDF
Abstract

2-Cyano-6-fluorophenylacetamide was explored as a novel P2 scaffold in the design of thrombin inhibitors. Optimization around this structural motif culminated in 14, which is a potent thrombin inhibitor (Ki = 1.2 nM) that exhibits robust efficacy in canine anticoagulation and thrombosis models upon oral administration.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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