Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds

A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure–activity relationship and biological results are presented.

Graphical abstractThe discovery and SAR of a new series of amino-acetonitrile derivatives (AAD) potent against parasitic nematode species are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide