Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376572 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A series of 2-phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among the tested compounds, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.
Graphical abstract2-Phenyl-1H-benzo[d]imidazole-4,7-diones were synthesized and tested for their inhibitory activity on the PDGF-stimulated proliferation of rat aortic vascular smooth muscle cells. Among them, 6-arylthio-5-chloro-2-phenyl-1H-benzo[d]imidazole-4,7-diones exhibited an potent antiproliferative activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chung-Kyu Ryu, Ra-Young Lee, Seung-Yon Lee, Hwa-Jin Chung, Sang Kook Lee, Kwang-Hoe Chung,