| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376573 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A new targeting potentially intravenous conjugate Amphotericin B (AMB)–star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a β-d-glucopyranoside molecular switch which is sensitive to β-glucosidases (E.C.3.2.1.21). The β-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC.
Graphical abstractThe prepared conjugate of Amphotericin B with star poly(ethylene glycol) represent a new targeting system which is sensitive to β-glucosidases (E.C.3.2.1.21).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Miloš Sedlák, Pavel Drabina, Eliška Bílková, Petr Šimůnek, Vladimír Buchta,