Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376575 | Bioorganic & Medicinal Chemistry Letters | 2008 | 8 Pages |
Abstract
Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.
Graphical abstractThe design and synthesis of novel diaryl ether NNRTIs with high levels of antiviral potency is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas J. Tucker, Sandeep Saggar, John T. Sisko, Robert M. Tynebor, Theresa M. Williams, Peter J. Felock, Jessica A. Flynn, Ming-Tain Lai, Yuexia Liang, Georgia McGaughey, Meiquing Liu, Mike Miller, Gregory Moyer, Vandna Munshi, Rebecca Perlow-Poehnelt,