Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376584 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
N-Substituted cyclam–amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam–peptide conjugates could interact with DNA in a highly selective manner.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
A. Venkata Ramana, Michael Watkinson, Matthew H. Todd,