Synthesis and DNA binding ability of cyclam–amino acid conjugates

N-Substituted cyclam–amino acid conjugates have been synthesised both in solution and on the solid phase. The DNA binding affinity of these species has been studied: the nature of the amino acid strongly influences the change in melting temperature suggesting that simple cyclam–peptide conjugates could interact with DNA in a highly selective manner.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide