| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376606 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
Graphical abstractA series of amides, based on the screening hit 2a, were prepared and profiled. Some potent IRAK-4-inhibitors were identified and two examples, 4a and 4b, were progressed into an in vivo PK study.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
George M. Buckley, Lewis Gowers, Alicia Perez Higueruelo, Kerry Jenkins, Stephen R. Mack, Trevor Morgan, David M. Parry, William R. Pitt, Oliver Rausch, Marianna D. Richard, Verity Sabin, Joanne L. Fraser,