| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376626 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Benzimidazolone derivatives were discovered as novel CB2 selective agonists. Structure Activity Relationship (SAR) studies around them were examined to improve metabolic stability. Compound 39 exhibited excellent metabolic stability in human liver microsomes (HLM) and significant attenuation of the chronic colonic allodynia in the TNBS-treated rats by po administration.
Graphical abstractBenzimidazolone derivatives as novel CB2 selective agonists are reported. Compound 39 exhibited excellent metabolic stability and significant attenuation of the visceral allodynia in a rat model by oral administration.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Hirofumi Omura, Makoto Kawai, Akiko Shima, Yasuhiro Iwata, Fumitaka Ito, Tsutomu Masuda, Atsuko Ohta, Naoya Makita, Kiyoyuki Omoto, Hiromi Sugimoto, Akira Kikuchi, Hiroshi Iwata, Kazuo Ando,