Article ID Journal Published Year Pages File Type
1376629 Bioorganic & Medicinal Chemistry Letters 2008 5 Pages PDF
Abstract

A series of milnacipran analogs were synthesized and studied as monoamine transporter inhibitors, and several potent compounds with moderate lipophilicity were identified from the 1S,2R-isomers. Thus, 15l exhibited IC50 values of 1.7 nM at NET and 25 nM at SERT, which were, respectively, 20- and 13-fold more potent than 1S,2R-milnacipran 1–II.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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