Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376629 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of milnacipran analogs were synthesized and studied as monoamine transporter inhibitors, and several potent compounds with moderate lipophilicity were identified from the 1S,2R-isomers. Thus, 15l exhibited IC50 values of 1.7 nM at NET and 25 nM at SERT, which were, respectively, 20- and 13-fold more potent than 1S,2R-milnacipran 1–II.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Junko Tamiya, Brian Dyck, Mingzhu Zhang, Kasey Phan, Beth A. Fleck, Anna Aparicio, Florence Jovic, Joe A. Tran, Troy Vickers, Jonathan Grey, Alan C. Foster, Chen Chen,