4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.

Graphical abstractThe synthesis and biological activity of selective inhibitors of 11β-hydroxysteroid dehydrogenase type I are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide