Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376647 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as potent inhibitors of genotype 1 HCV NS5B polymerase focusing on the optimization of their drug metabolism and pharmacokinetics (DMPK) profiles. This investigation led to the discovery of potent inhibitors with improved DMPK properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria V. Sergeeva, Yuefen Zhou, Darian M. Bartkowski, Thomas G. Nolan, Daniel A. Norris, Ellen Okamoto, Leo Kirkovsky, Ruhi Kamran, Laurie A. LeBrun, Mei Tsan, Rupal Patel, Amit M. Shah, Matthew Lardy, Alberto Gobbi, Lian-Sheng Li, Jingjing Zhao,