| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376649 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A novel oxachrysenone series (2) of nonsteroidal selective androgen receptor modulators (SARM) was developed based on the 6-aryl-2-quinolinones (1). Synthesis and preliminary SAR results based on in vitro assays are discussed. In the cotransfection assay, lead compound 5d showed AR agonist activity more potent than dihydrotestosterone (DHT), whereas compound 17b was a potent antagonist similar to bicalutamide.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shuo Zhao, Yixing Shen, Arjan van Oeveren, Keith B. Marschke, Lin Zhi,