| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376718 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in an animal model of diet-induced obesity is presented.
Graphical abstractOptimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided potent and selective compounds that are orally active in an animal model of obesity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Donald L. Hertzog, Kamal A. Al-Barazanji, Eric C. Bigham, Michael J. Bishop, Christy S. Britt, David L. Carlton, Joel P. Cooper, Alex J. Daniels, Dulce M. Garrido, Aaron S. Goetz, Mary K. Grizzle, Yu C. Guo, Anthony L. Handlon, Diane M. Ignar,