Article ID Journal Published Year Pages File Type
1376729 Bioorganic & Medicinal Chemistry Letters 2006 5 Pages PDF
Abstract

The discovery, synthesis and structure–activity relationship (SAR) of a novel series of EP1 receptor antagonists is described. Pyrazole acid 4, identified from a chemical array, had desirable physicochemical properties, an excellent in vitro microsomal inhibition and cytochrome P450 (CYP450) profile and good exposure levels in blood. This compound had an ED50 of 1.3 mg/kg in a rat pain model. A range of more potent analogues in the in vitro assay was identified using efficient array chemistry. These EP1 antagonists have potential as agents in the treatment of PGE2 mediated pain.

Graphical abstractThe discovery, synthesis, pharmacokinetic profile and structure–activity relationships of a novel series of EP1 receptor antagonists is described.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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