| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376733 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Analogues of suberoylanilide hydroxamic acid (SAHA) were prepared by replacing the Zn-binding group with squaric acid, N-hydroxyurea, and 4-hydroxymethyl oxazoline units, also varying the length of the aliphatic chain. No inhibitory activity on HDAC was observed below 1.0 μM and no cytotoxic activity on different tumor cell lines was seen below 20.0 μM.
Graphical abstractAnalogues of suberoyl anilide hydroxamic acid (SAHA) were prepared by replacing the Zn-binding group with squaric acid, N-hydroxyurea, and 4-hydroxymethyl oxazoline, also varying the length of the aliphatic chain.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen Hanessian, Valerio Vinci, Luciana Auzzas, Mauro Marzi, Giuseppe Giannini,