| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376737 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of α-benzylpropionylpiperazines were synthesized and tested as antagonists of the melanocortin-4 receptor. In addition to its high potency and selectivity, R-11a had desirable pharmacokinetic properties including high brain penetration in mice.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Caroline W. Chen, Joe A. Tran, Wanlong Jiang, Fabio C. Tucci, Melissa Arellano, Jenny Wen, Beth A. Fleck, Dragan Marinkovic, Nicole S. White, Joseph Pontillo, John Saunders, Ajay Madan, Alan C. Foster, Chen Chen,